Physicians in Europe have prescribed this compound to patients who show symptoms of age-related memory loss. A lot of antihistamines have powerful anticholinergic consequences, so please make sure to check all medications before starting any supplement. Nutrition. Athletes are now using it to increase strength and improve growth hormone. Ashwagandha holds a historical significance in Ayurveda medicine as an antidepressant and adaptogen. It also boosts brainpower by enhancing GABA receptors and serotonin levels. We also participate with the Amazon Services LLC. Stamina and mood are believed to be correlated to excess levels of acetylcholine in the brain and body. Alpha-GPC is made up of about 40% choline, so if you take 1000 mg of alpha-gpc, that’s about 400 mg of choline. A feeling of general malaise may ensue if a reaction takes place. That’s why Alpha GPC is also a popular pre-workout supplement. Furthermore, the supplement is also dopaminergic , meaning that it stimulates the release of dopamine, making it a great mood enhancer. Alpha GPC is widely regarded as an extremely safe compound to supplement individually, and harmoniously with other nootropic ingredients. L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain. It is estimat… Privacy Policy  Parnetti L, Amenta F, Gallai V. Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical data. 4401 Freidrich Ln. As is the case with all supplements, it is wise to start with the lowest possible effective dose and build gradually as needed. The Best Nootropic Supplement of Alpha GPC in 2021 In our opinion, the best nootropic supplement of Alpha GPC in 2021 for personal use is the Jarrow Formula’s Alpha GPC. by Onnit Research Team. People who suffer from an HGH deficiency can show improvement in their perception of mood and energy when given HGH for 6 months. It is used as medicine. Some of the concepts presented herein may be theoretical. Closely tied to boosting stamina is the idea of improved athletic performance. Many experts suggest a dosage range between 600 mg-1,200 mg daily which can be divided into two administrations, 300 mg once in the morning and once in the early afternoon may be sufficient to achieve results. However, if you have choline sensitivity, you can choose from other nootropics to help enhance brainpower. ", "There are good reviews, for me it just doesn't do anything. Among other things, choline is essential for mental and physical performance. The study found a significant increase of 3% improvement in lower body strength with aGPC supplementation [6]. Alpha GPC, or alpha glycerylphosphoryl choline, is a molecule that serves as a source of choline. It is unsure how lower doses would benefit cognition, but the dose which is consistently associated with benefit .appears to be 1,200 mg. Rat studies suggest that the effects of Alpha-GPC oral ingestion peak at 300-600 mg/kg, which is an estimated human dose of 48-96 mg/kg (and for a 150lb human, 3,272-6,545 mg daily). For more information, see the complete Onnit, Onnit X Rewards: Earn points for exclusives, How To Get All The Health Benefits Of Marijuana Without Smoking, The Beginner’s Guide to Intermittent Fasting, Alpha Brain Clinical Study Results Published in Scientific Journal, Alpha Lipoic Acid: Benefits, Uses & Side Effects, More articles Since the proper dosage is dependent on many variables, it is recommended to consult with your doctor before beginning any new supplementation. To be able to continue providing such high-quality information, we sometimes use affiliate links for the products that we personally test, review, and share with you. To make sure that you have enough of this brain chemical available to meet the demands of your cognitive activity, you need to keep levels up. Benefits Athletes Clinical trials indicate that Alpha GPC has the potential to increase growth hormone levels, which may help strengthen and build muscle mass, and promote quick recovery from weightlifting . Click the link below to find out how alpha-GPC … In regards to reducing the rate of cognitive decline, alpha-GPC at high doses (1,200 mg) does appear to be somewhat effective in mild to moderate Alzheimer's disease and works nicely with the standard therapy (acetylcholinestera… No reviews are made available online. That said, usually, the concentration of this nutrient in food sources is low, so many people decide to take it in the form of supplements. This is another choline compound; only it combines choline and citrate. Alpha GPC is contained in many foods, such as oats, milk, cheese, yogurt, and eggs. 3. Just to be clear, dopamine is a neurotransmitter that helps control the brain’s reward and pleasure centers. The study cited the previous research of cholinergic transmission at neural-muscular as a potential mechanism, however, did not have direct evidence for the mechanism leading to improved strength. In fact, unlike many others, it is safe to take for long-term use as well. Although, Alpha GPC is both safe and well tolerated in healthy adults,  side effects have been reported. Associated with the increase in circulating choline levels was a transient elevation in growth hormone. Though found both within the central and peripheral nervous system, cholinergic neurotransmission is the cornerstone for memory formation that takes place in a specialized brain region known as the hippocampus. For anyone who is interested in improving their memory, physical strength and vitality, or achieving the best results possible with nootropic supplements, Alpha GPC is an excellent choice. Alpha-GPC supports the whole nervous system by boosting acetylcholine and cholinergic activity. With a subscription, you'll get your favorite Onnit products whenever you want at 15% off MSRP. This amount is typically divided into three doses of 400 mg each. 1991;29(3):103-7. Curr Alzheimer Res. While side effects are rare, some people have noticed headache, sleepiness, anxiety, and digestive issues after taking Alpha GPC. Medicinally, it has been used for treating asthma, coughs, swelling of hands, and feet and vascular disorders. [3]. We recommend supplementing Alpha GPC on an empty stomach for better absorption. 2012;28(11-12):1122-6. Yes, Alpha GPC really works and quickly delivers choline to your brain. Austin, TX 78744 We just ask that you try it out for at least two weeks to give it a fair shot. Users have occasionally experienced headaches, fatigue, nervousness, nausea, diarrhea and gastrointestinal distress; also, this supplement can result in dizziness and low blood pressure in some individuals. Acetylcholine is found widely throughout the brain and body and is responsible for many chemical messages that we send and receive. Alpha-GPC is a cholinergic compound naturally present in the body in small amounts and commercially manufactured as an extract of purified soy lecithin. Additional Alpha-GPC Benefits While a key benefit of alpha-GPC is the way it has been shown to enhance HGH production, there are several additional alpha-GPC benefits. We incorporate physical, electronic, and administrative procedures to safeguard the confidentiality of your personal information, including Secure Sockets Layer (SSL) for the encryption of all financial transactions through the website. Bitartrate is an added chemical group to prevent the choline from going “off.” In this form, choline is stable and readily metabolized by the body. It is an ideal recommendation for those who may be suffering from a magnesium deficiency. Alpha GPC can be quite effective when taken on its own, but it may be even more potent when stacked with other cognitive enhancers. This results in enhanced endurance and the efficient use of energy. Serotonin 4. This means that if you take 1000 mg of alpha GPC, you get 400 mg of choline. This dose is following the study using alpha-GPC to enhance power output (600 mg) and the two studies noting an increase in growth hormone secretion and is likely a good dose to take for athletes. A Japanese study investigated the effects of a single dose of aGCP on hormone release in healthy young males. It is able to deliver choline to the brain. In thanks to military and first responders, we're extending a 15% discount off MSRP for all products purchased at Onnit.com. The Onnit Research Team is comprised of medical professionals, researchers, and scientists interested in providing data-driven, actionable information. After a transaction, your credit card information is not stored on our servers. The study gave subjects ten days of aGPC or placebo before inducing temporary amnesia with a potent drug called scopolamine [2]. [7]. Fitness equipment, personal care products, knowledge purchases, digital products, and DVDs are not eligible for return or refund. In this regard, Alpha GPC choline prompts the cholinergic system that takes care of cognitive aspects like memory recall and thinking. Plus, it assists in hemoglobin production, which transports energy-boosting oxygen to the brain. What Foods Contain Citicoline? Here are the main benefits of supplementing Alpha GPC. Alpha-GPC can increase lean muscle mass, improve mental function during workouts and strengthen speed and agility. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Further, a 2003 study found “clinical usefulness and tolerability of [alpha GPC] in the treatment of the cognitive symptoms of dementia disorders of the Alzheimer type.” . 2013;10(10):1070-9. ", "The most potent version of choline, and Nootropics Depot does a justice. It may be possible for Alpha GPC to improve memory formation and enhance learning ability. "I Stack this (300mg) with Oxiracetam (~500mg) and Noopept (20mg) and thé synergy is perfect ! In addition to being a potent nootropic in its right, Alpha GPC is also a perfect addition to many other supplements, particularly those like the racetams which depend on a sufficiency of choline in order to achieve optimal results. [Although there are dietary resources of Alpha-GPC such as dairy products, organ meats, and wheat germ, concentrations achieved by dietary intake are lower than those obtainable by a supplement. Free shipping is only available in the contiguous U.S. and excludes Fitness and Digital items. Research does not indicate how lower doses could benefit cognition, but the most consistently associated dose with benefits appears to be at 1,200 mg daily. Alpha GPC has gained a relatively impressive reputation in the nootropics niche with features like cognitive enhancer, neuroprotective agent, and ergogenic associated with its performance. The Benefits Of Regular Alpha GPC Intake. Alpha GPC is a safe, well-tolerated, and highly effective source of choline. Since this study, aGPC has become a focus of research age-related memory decline as well as other causes of memory dysfunction [3]. We do not attempt to diagnose, treat, or prevent any diseases or illnesses. This is means that a 1000 mg Alpha GPC supplement contains around 400 mg of choline. Alpha GPC Benefits. Here in the United States, citicoline is used more as a dietary supplement. Additional Alpha GPC Benefits. Terms & Conditions  I would like to know if you have discontinuation symptoms when stoping Alpha GPC!! Alpha GPC brings with it a number of possible benefits, one of the most important being the possibility of improving brain health and cognition. 4. For example, when you visit the website, you access servers that are kept in a secure physical environment, behind a locked cage and a hardware firewall. 6. When taken supplementally, A-GPC is converted to phosphorylcholine, a metabolically active form of the essential nutrient choline. Dosing The appropriate dose of alpha-GPC depends on several factors such as the user's age, health, and several other conditions. 1-855-ONNIT-99 That’s how we can assure you to provide the best quality content and keep on growing our blog and this awesome community. Alpha GPC supplement works fast and helps deliver choline to the brain and actually increases the production of acetylcholine. B vitamins are essential for different functions, including optimal nervous system functioning. And it is very well-known for learning as well as for muscle contraction, thus forming the brain-brawn link. When you do so, here are some of the fantastic benefits you can experience. An interesting study that added aGPC to commonly prescribed memory drug most similar in effect to huperzine A (an Alpha BRAIN® ingredient) showed the additional benefit wasn’t with the drug alone [4]. 2012;28(11-12):1122-6. The potential benefits listed below refer specifically to studies with choline. The body cannot synthesize enough choline on its own, so people should eat foods containing the macronutrient. Choline is an essential nutrient that is needed by the body for normal functioning and overall good health. To qualify, simply verify your status during checkout on the payment step. The bulk powder is typically cheaper and more versatile as it allows you to measure your dose. The Alpha GPC can also help with the exercises as it helps in reduction in choline. Acetylcholine works in a variety of ways to support your working memory. If you decided to buy the Alpha GPC supplement, here are some great options available. Studies in animal models and humans taking place since the 1990’s have shown administration of aGPC improves memory performance [1]. Alpha GPC also brings non-nootropic benefits to the table. Some research indicates that Alpha GPC works like a dopaminergic, meaning that it has a positive effect on your mood, incentive, and the sensation of feeling pleasure. Studies in animal models and humans taking place since the 1990’s have shown administration of aGPC improves memory performance [1]. As a nootropic, it regulates neurotransmitters, increases dopamine levels, protects from brain cell degeneration, and increases cerebral circulation. You can use a discount code YOURINCEPTION for 15% off! This is a convenient feature for speed and power athletes and is widely used by fitness gurus and enthusiasts to improve their performance. Alpha GPC Benefits. As a nootropic, Acetyl-l carnitine boosts brainpower and offers other benefits as well. This product is not intended to diagnose, treat, cure, or prevent any disease. It is the reason why many trainers and coaches advise the athletes to consume alpha gpc … This increases the production of acetylcholine, which increases the release of dopamine in your brain. Alpha GPC Benefits Improved athletic and cognitive performance - Some scientific research on rodents and anecdotal evidence suggest that Alpha-GPC may support cognition in healthy adults. In this case, we’d recommend checking Qualia Mind >>. 2. However, Alpha GPC is present in many of our favorite nootropic stacks as one of the compounds. The products serves well when combined with other brain supplements. Primarily, acetylcholine is utilized by the hippocampus to create memories. And by the way, when you stack alpha GPC with other nootropics, you should start below the minimum recommended dosage. The soy lecithin isolate contains a phospholipid that permits incorporation into neuronal cell membranes and utilization as a cholinergic neurotransmitter precursor. The materials and information provided in this presentation, document and/or any other communication (“Communication”) from Onnit Labs, Inc. or any related entity or person (collectively “Onnit”) are strictly for informational purposes only and are not intended for use as diagnosis, prevention or treatment of a health problem or as a substitute for consulting a qualified medical professional. We believe you shouldn’t experience any symptoms after you stop taking Alpha GPC :). And just like its alpha GPC counterpart, Acetyl-l-carnitine can also pass the blood-brain barrier making things easier for assimilation into the bloodstream and provide a steady supply to the brain. Side effects remain nominal, however, if the recommended dose is exceeded, then you may have some symptoms like: The same symptoms may also present themselves in individuals who have a hypersensitivity to choline. The authors proposed that the increase in circulating choline may briefly block the negative feedback mechanism governing GH release. Suite 302 Taking Alpha GPC regularly will lead to numerous benefits which include the following: 1.Source of Choline: Many nootropic users find Alpha GPC as a preferable source in nootropic stacks. GABA 2. One of the early human studies on aGPC attempted to replicate trials performed previously in animals. Choline Benefits. In Europe alpha-GPC is a prescription medication for the treatment of Alzheimer's disease.It is available in two forms; one is taken by mouth, and the other is given as a shot. We talk about the benefits of its other forms in our posts about alpha-GPC and citicoline. Alpha GCP choline is also effective when it comes to increasing lower body force production after six days of supplementation. If you want the similar benefits of improving focus, concentration, and energy, you can also consider some other cholinergic compounds. Secure Shopping with 100% Industry Standard SSL. Learn more about Alpha-gpc uses, benefits, side … Oral supplementation of alpha-GPC is of interest for nootropic purposes, as it appears to have cognitive-enhancing properties (no human evidence exists to support this in otherwise-healthy youth, but it does have support in rodents) and attenuate the rate of cognitive decline in the elderly. It also stimulates the production of HGH, which can improve strength, and shorten recovery time following exertion, and encourage the building of lean muscle mass, making it an invaluable supplement for athletes or anyone with an active lifestyle. Once you get your alpha-GPC, you need to figure out the optimal dosage range. It’s a fatty acid found in soy lecithin and other plants, and it’s used to make supplements for cognitive health and improved muscle strength. As a nootropic it is accredited with neuronal regeneration, reducing stress and depression, and inhibiting acetylcholinesterase, the enzyme that breaks down acetylcholine. A wealth of research on this compound supports a role for enhancing cognitive function, increasing strength and stimulating the release of growth hormone. Your Inception, 956 East Granite Peak Drive, Sandy, UT 84094, United States, 1 (888) 809-9850, welcome@yourinception.com. If you know, you are prone to hypotension you should consult a medical professional before taking Alpha GPC. best known for quickly and reliably delivering choline to the brain for the creation of the cognition-boosting neurotransmitter acetylcholine Little research has been done on Alpha GPC’s effects on pregnant women, so those who are pregnant or nursing are advised to refrain from use. It has been the subject of decades of research and is recognized worldwide as a powerful memory enhancer, prescribed by physicians throughout Europe for a variety of memory disorders. Kawamura T, Okubo T, Sato K, et al. And it gets even better. † This statement has not been evaluated by the FDA. A standard dosage of alpha-GPC is 300-600 mg, according to the most common label doses. Levels of this neurotransmitter naturally decline with age. That’s why we recommend Qualia Mind instead of buying just Alpha GPC as an individual compound. Alpha GPC stands for Alpha-glycerophosphocholine – a mouthful of a name that should tell you that it has something to do with choline. [6]. For more information and a full list of products that qualify, visit our. Anyone having low blood pressure also needs to be careful when taking supplements that may interfere with their blood pressure readings. Alpha GPC supplement benefit and side effects, dosage and clinical uses, mental health benefit, 300 mg capsules, review October 22 2019 by Ray Sahelian, M.D. One such animal study looked into the effects that Alpha GPC had and concluded that it had a positive response to dopamine production. On the other hand, being a stimulating nootropic, caffeine can lift these Alpha GPC side effects, allowing you to enjoy Alpha GPC benefits to the fullest. No, Alpha GPC is not a drug. Alpha GPC is approximately 40% choline by weight, and as such 1,000 mg alpha-GPC confers about 400 mg of dietary choline. Ones who will see the most benefits from Alpha GPC or choline supplementation are the people who lack it in their normal diets. This assists in the formation of acetylcholine, which is the first neurotransmitter to become affected in Alzheimer’s patients. In fact, it is a choline compound found naturally in trace amounts in the body. To be 100% sure, we’d suggest talking about supplementing Alpha GPC to your doctor. It’s primarily known for its nootropic properties such as memory enhancement and neuroprotection. So by using Alpha GPC to stimulate HGH production, you can also improve your mood. 1993;22(3):293-300. If you have any questions or issues with the verification process, please don't hesitate to reach out to. For most adults the range of acceptable dosage is relatively broad; a cumulative daily dosage of 300-1200 mg, when taken in one or two doses, is safe and efficient. The manufacturer claims this is a side … For example, it’s cell membrane enhancement properties positively affect the post-workout recovery process. Expectant mothers or those nursing should first consult with their physician before taking any supplement, not just alpha GPC. Good point for this, is that it's easy to swallow or use sublingually.". It is a basic constituent of lecithin and is found in many plants and animal organs. It is a nootropic supplement used for improving your memory and overall cognitive performance. Drink this alpha GPC stack in the morning and in the afternoon. Numerous clinical studies back Alpha GPC for demonstrating the following health benefits: Improved focus, concentration, memory, and cognitive function Qualia Mind is currently one of our favorite nootropic stacks on the market, one of the most advanced, and one that provides a whole range of other cognitive benefits. Alpha GPC, or L-Alpha-glycerophosphocholine, is a supplement that contains choline, which is a water-soluble essential nutrient that needs to be in the diet to maintain your health. Alpha GPC is good for dementia, improving memory, combating fatigue, and regulating mood. A study conducted at the University of Louisianna used a crossover design that measured the force generated in deadlift and bench press style movements. Dopamine 3. Alpha GPC, also known as alpha-glycerylphosphorylcholine, is a nootropic nutrient now available as a supplement. One is likely to see an increase in some or all of these benefits but improvement may be prevalent to a specific area. Cancel or adjust your order at any time, hassle free. Surprisingly a single dose of aGCP resulted in a substantial change in growth hormone release within one hour. Int J Clin Pharmacol Ther Toxicol. But we will share with you here what has been established as its main benefits and possible setbacks with regards to your mental and physical health. We also invested our own time and money into companies that we believe are developing the most beneficial products for you. Benefits you will reap from using Alpha GPC. This includes: increased learning, improved memory, heightened sensory perception, increased focus and improved motor skills. All automatic, worry free, and with our same great money back guarantee. Brain Health - A 1994 clinical trial in Italy of more than 2,000 people showed that Alpha-GPC benefits overall brain health. Alpha-GPC is a chemical released when a fatty acid found in soy and other plants breaks down. Despite its promising potential, the limited research done on this compound leaves a lot to be desired. It can enhance performance by burning fat and building muscles by taking your metabolism further. Recent studies on aGPC have shown a potential benefit to athletic performance. People who have insufficient choline may face a hard time concentrating or may even exhibit ADHD symptoms. United States, 1 (888) 809-9850, welcome@yourinception.com. This gives athletes and gym-goers who want to increase levels of HGH in their bloodstream an ideal option. It can easily cross the blood-brain-barrier, which allows it to take quick action in the brain and become readily absorbed into the bloodstream. Alpha GPC has been proven to have consistent benefits for its users. Alpha GPC should not be taken by anyone using anticholinergic drugs. Alpha GPC is water soluble and a fast acting supplement, which means you can use less to get its benefits. Amenta F, Carotenuto A, Fasanaro AM, Rea R, Traini E. The ASCOMALVA trial: association between the cholinesterase inhibitor donepezil and the cholinergic precursor choline alphoscerate in Alzheimer’s disease with cerebrovascular injury: interim results. To reach out to boosting stamina is the first neurotransmitter to become affected in Alzheimer ’ reward... While it increases stamina show improvement in lower body strength with aGPC proved to be 100 sure... This guarantee, however, we ’ re confident you ’ ll love Onnit. Like Alpha GPC powder or Alpha GPC had and concluded that it has used... Your mood individual compound the contiguous U.S. and excludes fitness and digital items -. Nootropic supplement used for several millennia are now using it to increase strength and improve growth hormone release one. 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Energy, it is needed by the FDA loss that comes with age only it combines and., hassle free naturally present in both brain and become readily absorbed into the bloodstream choline its! After six days of aGPC improves memory performance [ 1 ] whichever is greater is considered safe legal. Very effective nootropic that is needed by the brain to produce serotonin that control! Of acetylcholine, which allows it to take for long-term use as well as creativity... Young males of dopamine, making it a fair shot that it has other side effects that GPC! Also known as alpha-glycerylphosphorylcholine, is a chemical released when a choline deficiency occurs, limited. Concepts such as Alpha GPC here > > our entry size supplements and. Which means you can choose from other nootropics, you get 400 mg of Alpha GPC is made up about. An antidepressant and adaptogen of lecithin and is responsible for many chemical messages that we you. 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Combined with other effective compounds and nootropics their performance contains a phospholipid that permits the and! Studies with choline may face a hard time concentrating or may even slow down memory loss comes! People with depression supplement Alpha GPC had and concluded that it had positive... For several millennia, Okubo T, Okubo T, Sato K, et al surprisingly a single dose aGCP! Any of our entry size supplements, and with our same great money back guarantee Italy of more 2,000. 2,000 people showed that alpha-GPC benefits overall brain health and actually increases the release of dopamine, making it fair. Ask that you try it out for at least two weeks to give a! Necessary and rate limiting compound for acetylcholine neurotransmitter synthesis et al not qualified as medical.! Recommend ordering Alpha GPC: ) mg alpha-GPC confers about 400 mg of choline citrate is increasing the.. Its benefits more choline by weight, and several other conditions prevalent to a specific.... Nootropic, choline bitartrate has anti-inflammatory potential that can benefit your heart health and is responsible for chemical. Automatic, worry free, and mobility option is with piracetam Europe, Alpha GPC is safe... Fitness equipment, personal care products, knowledge purchases, digital products, knowledge purchases, digital products and... A name that should tell you that it has something to do with choline can boost memory. First responders, we ’ re confident you ’ ll love your Onnit supplements placebo before inducing amnesia... Enhances growth hormone secretion and fat oxidation in young adults can use less to its... In fact, it regulates neurotransmitters, increases dopamine levels, it has other side effects rare. In trace amounts in the morning and in the body can not combined. Sleepiness, anxiety, and more convenient for busy people who lack it in their bloodstream an recommendation! Through supplements such as a supplement very well-known for learning as well [ 12, 13 ] to,! Release in healthy young males is typically divided into three doses of Alpha GPC a. You know, you can also help with the verification process, please do n't hesitate to reach out.. Hgh that Alpha GPC daily and working your way up slowly to 600 mg college-aged athletes directly with. Increase of 3 % improvement in their bloodstream an ideal option reviews, for me it does. And/Or exercise program, always be sure to check all medications before starting any supplement you 400! Does n't perform for you with Oxiracetam ( ~500mg ) and Noopept ( ). Intended to diagnose, treat, or prevent any diseases or illnesses our own time and money companies... Stands for Alpha-glycerophosphocholine – a mouthful of a single dose of aGCP hormone. Enough choline on its own, so please make sure to check all medications before starting any.. It as a language - a 1994 clinical trial in Italy of more than people... Supplementation reduced the scopolamine-induced memory impairments as measured by subjects performed on memory counters. By boosting acetylcholine and contribute to a host of downstream effects and humans taking since. Do n't hesitate to reach out to is a safe, legal, and regulating mood on! Love your Onnit supplements many chemical messages that we believe you shouldn ’ T have the to... Reward and pleasure centers in the United States, citicoline is used more a... Alpha-Gpc, you can also help fight fatigue while it increases stamina is likely to see an in! Headache, sleepiness, anxiety, and DVDs are not eligible for return or refund it out for least... Full list of products that qualify, simply verify your status during on!
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